No effect of polymorphisms in catechol-O-methyltransferase was observed to be connected with postoperative oxycodone usage. The pharmacodynamics of oxycodone is usually depending on polymorphic enzymes CYP2D6 and CP3A.If your agony is just not nicely managed by oxycodone or you've got any new or unanticipated side effects, see your health care prov